You Kill Me is a comedy about an alcoholic hit man who must protect his Buffalo mob family from an Irish gang. As a punishment for a recent gaff he is sent to San Francisco to deal with his addiction and lay low for a while. While in California he gets a job at a mortuary and attend meetings for addicts. In the process, he gets involved with Laurel, who is played by Tea Leoni. The two are eventually forced to team up and battle with the rival mob.