The group released several underground albums before receiving any mainstream success. In 2006, Three 6 Mafia made history by being the first rap act to ever perform on the Academy Awards. Their song, "It's Hard Out Here for a Pimp", featured on the Hustle & Flow soundtrack won an Academy Award for Best Song.

• Juicy J
• DJ Paul

• 1995: Mystic Stylez
• 1996: Chapter 1: The End
• 1997: Chapter 2: World Domination
• 2000: When the Smoke Clears: Sixty 6, Sixty 1
• 2001: Choices: The Album
• 2003: Da Unbreakables
• 2005: Choices II: The Setup
• 2005: Most Known Unknown
• 2008: Last 2 Walk

• 1994: "Beatin' Them Hoes Down"
• 1994: "Squeeze My Nuts"
• 1994: "Now Im High Really High"
• 1995: "Live By Yo Rep
• 1995: "F***** wit Dis Click"
• 1995: "Mystic Styles"
• 1995: "Porno Movie"
• 1995: "Tear Da Club Up"
• 1998: "Late Nite Tip"
• 1998: "Tear da Club Up '97"
• 2000: "Who Run It"
• 2000: "Sippin' on Some Syrup"
• 2000: "Tongue Ring"
• 2001: "Baby Mama"
• 2001: "2-Way Freak"
• 2003: "Ridin' Spinners"
• 2005: "Stay Fly"
• 2006: "Poppin' My Collar"
• 2006: "Side 2 Side"
• 2007: "Doe Boy Fresh"
• 2007: "Like Money"
• 2008: "I'd Rather"
• 2008: "Lolli Lolli (Pop That Body)"