The Girls Next Door Season Premiere

- Season premiere: Sunday at 10:30 p.m. EST
- Network: E! Entertainment Television
- First aired: August 7, 2005
- Current season: 6
- Producer: Kevin Burns
- Creators: Kevin Burns, Hugh Hefner
- Filming location: Los Angeles, California

The season premiere for the sixth season of The Girls Next Door airs at 10:30 PM on Sunday, October 11, 2009. The Girls Next Door is a reality television show on the E! Network that follows Hugh Hefner, the founder of Playboy Magazine, and his three girlfriends. This season three new girls, Crystal Harris and twins Karissa and Kristina Shannon replace the girls from last year, Kendra Wilkinson, Holly Madison and Bridget Marquardt.
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