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- Symptoms: blindness, deafness, muscle atrophy, paralysis, dementia, seizuresNational Institutes of Health: NINDS Tay-Sachs Disease Information Page
- Symptoms begin to appear at 3-6 months of ageGenetics Home Reference: Tay-Sachs disease
- Children with Tay-Sachs disease usually die by the age of 4National Institutes of Health: NINDS Tay-Sachs Disease Information Page
- Tay-Sachs patients have 'cherry-red' spots in their eyesNational Institutes of Health: NINDS Tay-Sachs Disease Information Page
- There is no treatment or cure for Tay-Sachs, although some medications to control symptoms may work and extensive research is in progressNational Institutes of Health: NINDS Tay-Sachs Disease Information Page
- Rare in the general human populationGenetics Home Reference: Tay-Sachs disease
- On average, 16 cases of Tay-Sachs are diagnosed in the United States each yearKidsHealth: Tay-Sachs Disease
- About 1 in 250 people in the general population is a carrier of the Tay-Sachs geneKidsHealth: Tay-Sachs Disease
- The gene is recessive, so both parents must carry the gene for a child to develop itNational Institutes of Health: NINDS Tay-Sachs Disease Information Page
- High prevalence in people of Eastern European and Askhenazi Jewish descentGenetics Home Reference: Tay-Sachs disease NTSAD: What is Tay-Sachs Disease
- About 1 in 27 Ashkenazi Jews is a carrierKidsHealth: Tay-Sachs Disease
- High occurrence also noted in French-Canadian in Quebec, Old Order Amish in Pennsylvania (Pennsylvania Dutch), and Cajun in LouisianaGenetics Home Reference: Tay-Sachs disease NTSAD: What is Tay-Sachs Disease
- Preliminary data seems to suggest that people from Italy and the British Isles may have a higher occurrence of carriersNTSAD: What is Tay-Sachs Disease
- The presence of the gene may be detected with a simple blood testNational Institutes of Health: NINDS Tay-Sachs Disease Information Page
- The disease may be detected in fetuses at 10-12 weeksKidsHealth: Tay-Sachs Disease
- The gene is recessive, so both parents must carry the gene for a child to develop Tay-SachsNational Institutes of Health: NINDS Tay-Sachs Disease Information Page
- Named for ophthalmologist Warren Tay and neurologist Bernard SachsNTSAD: What is Tay-Sachs Disease
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Tay-Sachs disease is a fatal genetic disorder that is caused by the inefficient activity of an enzyme. Gangliosides are fatty substances (lipids) that develop in humans throughout life and are normally biodegraded regularly. In a normally functioning human system, the enzyme beta-hexosaminidase A (Hex A) controls the biodegradation of gangliosides.
If Hex A does not operate correctly, the gangliosides do not degrade but instead build up on nerve cells and tissue in the brain, causing a rapid and devastating deterioration of mental and physical abilities.National Institutes of Health: NINDS Tay-Sachs Disease Information Page
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did y'all know Tay-Sachs disease effects 1 in every 200 humans!! Learn something new everyday. If you can't tell I'm sitting in biology!!
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Short Facts about Tay Sachs Disease, Wilson's Disease and Cystinosis http://tinyurl.com/ljv7we
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