Quake 4 is a first-person shooter video game available for the PC and the Xbox 360. Quake 4 is a sequel to Quake 2 and set during the same war as Quake Wars. This game was developed by Raven Software, in conjunction with id Software, the original developers of the Quake series. Quake 4 was released for the PC console on October 18, 2005. The Xbox 360 version, based on the Special Collector's Edition, was then released on November 22, 2005.

When you are in single player mode, the story line of Quake 2 continues. Matthew Kane is a marine and a member of Rhino Squad. The squad is assigned to take over the cyborg alien Strogg's planet.

In the middle of the invasion, Kane's ship is hit and it crashes in the war zone, where he is separated from the rest of the squad. At some point, Matthew locates them again and helps to defeat Strogg by capturing and destroying aircraft hangars and their defense systems. After this fight, the remaining marines and Matthew find their way back to the USS Hannibal for their next mission.

They are now assigned to get into the Strogg's Central Communications Hubs, Tetranod, with a bomb in hopes of confusing the Strogg. After many of his men die, Matthew and two of his fellow comrades, Private Johann Strass and Lance Corporal Nikolai Slidjonvitch, are left to complete the mission. When they reach Tetranod, they are met by the new Makron, Skogg's leader, and Matthew is knocked out.

Upon awakening he finds that he is strapped to a conveyor belt in Strogg's hospital, used to turn the captured into protein food or Strogg Units. Most of his anatomy is replaced with bio-mechanical parts. Before he is transformed into a Skogg, the Rhino Squad rescue Matthew Kane. While he is trying to escape, Kane meets his former commander, Lieutenant Scott Vass who is now a Skogg.

After beating Voss, Kane and the remaining marines make it back to the Hannibal. Realizing that Kane could now get into Skogg territories, they come up with a new plan to reach the Nexus Core. Kane reaches the core, destroys it and returns to the Hannibal, where he awaits orders for his next mission.