On May 4, 2009, NBC announced that beginning in Fall 2009, Krause will be starring in Parenthood, a TV version of the hit 1989 movie and produced by Ron Howard and Brian Grazer.TV Guide: NBC Unveils Fall Lineup, Including Parenthood... (May 4, 2009)

• Krause attended the Gustavus Adolphus College. While he was there he tried acting, but graduated with a degree in English literature. He moved to New York City and attended the New York University. He finished his Masters in the Fine Arts Acting Program.

• In 1998 Krause got a roll as "Casey McCall" on ABC's Sports Night. The show was created by Krause's friend Aaron Sorkin, whom he met while working as a bartender while he lived in New York. The show was canceled in 2000 after only two seasons because of the lack of audience.

• In 2001 Krause starred in the Bravo and HBO series Six Feet Under. The series ran for five seasons and ended in 2006.

• By 2007 he landed another lead roll as Nick George in the ABC series Dirty Sexy Money.

• In 2009, it was announced that he will star as the lead role of Gil Buckman in the NBC series Parenthood