Epps made his acting debut in the movie Juice alongside Tupac Shakur. From there he went on to star in The Program. Since the beginning of his career he has appeared in other movies like Major League II, Scream 2, The Mod Squad, Love & Basketball, Against the Ropes and Alfie.

Aside from House M.D., Epps can next be seen in Love Can't Hide, which is slated for release sometime in 2008.

"Before ER a lot of people knew my name and some people knew my face. I saw big difference after ER, like, wow, I didn't know television was that powerful." — Omar Epps on life before ER

"I've been writing since I was a kid. Short stories, poetry, and all of that, and acting is just an extension of that. It just came naturally. So it's coming full circle." — Omar Epps on his personal writing

"I'm an avid fan of boxing, so the eagerness was there, the desire was there but I dunno...physically, this was the most I ever put my body through." — Omar Epps on boxing

"I believe success is preparation because opportunity is going to knock on your door sooner or later but are you prepared to answer that?" — Omar Epps on success