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Possible Side Effects Check with your doctor if any of these most common side effects persist or become bothersome: * agitation; back pain; constipation; dizziness; drowsiness; dry mouth; headache; indigestion; runny nose; sore throat; stomach pain; weakness; weight gain. Seek medical attention right away if any of these severe side effects occur: * severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); altered mental abilities, including lack of response to your surroundings; high blood sugar (eg, thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, or fruity breath odor); increased or irregular heartbeat; involuntary, uncontrolled muscle movements; lightheadedness when rising from a seated or lying position; muscle stiffness; sweating; tremor; unexplained fever; vision changes. More Information Seroquel is to be used only by the patient for whom it is prescribed. 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