Fleury was sidelined for 12 games during the 2008-09 season with a groin injury and is expected to the Penguins on December 18, 2008.ESPN.com: Pittsburgh Penguins' Marc-Andre Fleury to Start for First Time in over a Month

During the 2004-2005 NHL labor dispute, Fleury played with the Penguins' American Hockey League affiliate, the Wilkes-Barre/Scranton Penguins, and began the following season with them. In late November, he was called up to play the rest of the season in Pittsburgh. Although the team fared poorly, again due to their poor defensive line, Fleury did relatively well and earned a better save percentage than either of the team's other two goalies. His performance impressed the Penguins' management, who signed him to a two year contract worth $2.59 million.

In April of 2007, Fleury became the second Penguins goalie to win 40 games in a season. On a team that has struggled with defense for many years, Fleury has been instrumental in the Penguins' reaching the Eastern Conference finals in the 2008 Stanley Cup Playoffs.