The sixth and last season will conclude the television series.

• "Let's face it: absence makes the heart grow fonder, but there's nothing sweeter than a reunion. All we're willing to say at this point is that if we were to spend the entire duration of season 5 with the Oceanic Six trying to get back to the island, we are fully aware that the audience would strangle us."—Damon LindelofBuddy TV: Lost Execs Drop Hints About Season 5 (December 2, 2008)

• After the crash of Oceanic Air flight 815 onto a Pacific island the survivors band together to survive until they can be rescued. In order to stay alive the Oceanic Six must overcome a strange smoke monster, polar bears, a mysterious French woman and "The Others", a potentially dangerous group of island residents.Official Site: About Lost

• Naveen Andrews as Sayid Jarrah
• Nestor Carbonell as Richard Alpert
• Henry Ian Cusick as Desmond Hume
• Jeremy Davies as Daniel Faraday
• Michael Emerson as Ben Linus
• Matthew Fox as Jack Shephard
• Jorge Garcia as Hugo 'Hurley' Reyes
• Josh Holloway as James Sawyer Ford
• Daniel Dae Kim as Jin Kwon
• Yunjin Kim as Sun Kwon
• Ken Leung as Miles Straume
• Evangeline Lilly as Kate Austen
• Rebecca Mader as Charlotte Lewis
• Elizabeth Mitchell as Dr. Juliet Burke
• Terry O'Quinn as John Locke