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Jack Shephard
- Full name: Jack Shephard
- Portrayed by: Matthew Fox
- Age: 37
- Citizenship: United States
- Origin: Los Angeles, California
- Occupation: Surgeon at "St. Sebastian Hospital"
- Seat number: 23A
- Travel reason: Returning home after recovering his father's body in Australia
Kate
- Full name: Katherine Anne Austen
- Portrayed by: Evangeline Lilly
- Citizenship: United States
- Origin: Sioux City, Iowa
- Occupation: Fugitive from the law
- Seat number: 27H
- Travel reason: Being extradited to United States in custody of U.S. Marshal
Sawyer
- Full name: James Ford Sawyer
- Portrayed by: Josh Holloway
- Citizenship: United States
- Origin: Knoxville, Tennessee
- Occupation: Confidence man
- Travel reason: Searched Australia for man who led his father to murder his mother, then kill himself
Hurley
- Full name: Hugo Reyes
- Portrayed by: Jorge Garcia
- Citizenship: United States
- Origin: Los Angeles, California
- Age: 27
- Occupation: Business owner and investor
- Seat number: 20G
- Travel reason: Returning home from trip to see "Sam Toomey" in Australia about the "numbers"
Sayid
- Full name: Sayid Jarrah
- Portrayed by: Naveen Andrews
- Age: 36
- Citizenship: Iraq
- Origin: Tikrit, Iraq
- Occupation: Forced to work undercover with CIA
- Travel reason: Flying to LA to find "Nadia"
Locke
- Full name: Johnathan Locke
- Portrayed by: Terry O'Quinn
- Age: 48
- Citizenship: United States
- Origin: Tustin, California
- Occupation: Regional Collections Supervisor for a box company
- Seat number: 24D
- Travel reason: Returning home from failed walkabout tour in Australia
Charlie
- Full name: Charles Hieronymus Pace
- Portrayed by: Dominic Monaghan
- Age: 25
- Citizenship: Great Britain
- Origin: Manchester, England
- Occupation: Singer
- Seat number: 29C
- Travel reason: Traveling to LA to start a new tour after visiting brother
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