When the Super Bowl runner-up Indianapolis Colts take the field for the 2010 National Football League season they will play 16 games during the regular season, eight each at home and on the road. While they know their opponents, as well as if they will host or visit each team, is known, the dates, times and television coverage of all 16 regular season games and their four pre-season games was announced in April 2010, with the remainder of the 2010 NFL schedule.

In accordance with NFL rules, the Colts will host and visit each of their AFC South rivals, including the Houston Texans, Jacksonville Jaguars and Tennessee Titans. They will also play each of the four teams from the AFC West, the Denver Broncos, Kansas City Chiefs, Oakland Raiders and San Diego Chargers, as well as all four teams from the NFC East, the Dallas Cowboys, New York Giants, Philadelphia Eagles and Washington Redskins. The final two games will be against the AFC East and AFC North teams that finished the season atop their respective divisions, as the Colts did in 2009, the New England Patriots and Cincinnati Bengals respectively.http://www.colts.com/sub.cfm?page=schedule

During the 2009 season, the Indianapolis Colts were a top contender, as veteran quarterback Peyton Manning led the team to a 14-2 record. They began the season with a perfect 14-0, then pulled their starters in week 16, falling to the New York Jets that week and the Buffalo Bills in their final regular-season match.http://www.colts.com/sub.cfm?page=schedule

The 14-2 record allowed them the top seed in the American Football Conference as well as home-field advantage throughout the NFL Playoffs. Indianapolis easily defeated the Baltimore Ravens 20-3 in the NFL Divisional Weekend as well as the New York Jets in the AFC Championship Game with a score of 30-17 to reach the Super Bowl. Their luck however ran out as they fell to the New Orleans Saints in Super Bowl XLIV 31-17.http://www.colts.com/sub.cfm?page=schedule