On Monday September 21, the season premier of House M.D. aired on Fox kicking off season 6.

In the episode "Simple Explanations", which originally aired on April 6, 2009, Kal Penn's character Lawrence Kutner was found dead in his home with a gunshot wound to his head. Kutner's suicide shocked his co-workers, particularly Dr. House. Penn departed the show to accept a position as Associate Director in the White House Office of Public Liaison in the Obama administration.EW: House Exclusive (April 7, 2009)

• House was created by David Shore, who also produced the show along with film director Bryan Singer. Set at the fictional Princeton-Plainsboro Teaching Hospital in New Jersey, House's colleagues include oncologist James Wilson (Robert Sean Leonard), House's only friend and Dr. Lisa Cuddy (Lisa Edelstein), the Dean of Medicine and hospital administrator who continually butts heads with House and his unconventional methods. For the first several seasons, House's team consisted of Dr. Eric Foreman (Omar Epps), Dr. Allison Cameron (Jennifer Morrison) and Dr. Robert Chase (Jesse Spencer).

• After Foreman, Cameron and Chase also left House, or were fired, House is forced to select a new team. Season four began with 40 doctors competing for the opportunity to work with House and by the end of the season he narrowed it down to the winners, Dr. Chris Taub (Peter Jacobson), Dr. Lawrence Kutner (Kal Penn) and Dr. Remy "Thirteen Hadley (Olivia Wilde). One of his rejected doctors, Dr. Amber Volakis (Anne Dudek), became Wilson's love interest.Official Site: House

• "Everybody Lies"—Episode: PilotTV Squad: House's 100th Episode (February 2, 2009)

• "No, if you talk to God, you're religious. If God talks to you, you're psychotic."—Episode: House vs. God"TV Squad: House's 100th Episode (February 2, 2009)

• "Dying people lie too. Wish they'd worked less, been nicer, opened orphanages for kittens. If you really want to do something, you do it. You don't save it for a sound bite."—Episode: "Hunting"TV Squad: House's 100th Episode (February 2, 2009)

• "I thought I'd get your theories, mock them, then embrace my own. The usual."—Episode: "Merry Little Christmas"TV Squad: House's 100th Episode (February 2, 2009)

• "We're both (Laurie and House) quite serious but also have childishness. He and I are eternal adolescents but with this morbid gravity. The other thing is, we both have issues with joy, insomuch as we think it's beyond us. I often picture that scene in the Woody Allen movie when he's on the train and looks into another car that's full of people laughing. They're drinking champagne; somebody has a trombone. And Woody is very much on the outside of that, looking in. I'd say that sums up my view of the world, as well as House's."—Hugh LaurieUs Magazine: Hugh Laurie (January 14, 2009)

• Hugh Laurie as Dr. Gregory House
• Lisa Edelstein as Dr. Lisa Cuddy
• Omar Epps as Dr. Eric Foreman
• Robert Sean Leonard as Dr. James Wilson
• Jesse Spencer as Dr. Robert Chase
• Jennifer Morrison as Dr. Allison Cameron
• Kal Penn as Dr. Lawrence Kutner
• Olivia Wilde as "Thirteen"/Dr. Remy Hadley
• Peter Jacobson as Dr. Chris Taub

611: The Down Low "Sway" - Dean Martin "Maggot Brain" - Funkadelic "One" - Original Broadway Cast recording of "A Chorus Line" "One" - (Wilson sings)

610: Wilson "Faith" (House sings and plays guitar) "A Slow Parade" - A.A. Bondy

609: Ignorance is Bliss "Games People Play" - James Taylor "Enditol" - James Taylor

608: Teamwork "Golden Cage" - The Whitest Boy Alive "Where Did You Go" - Jets Overhead

607: Known Unknowns "Stadium Love" - Metric "Fuel" - Metallica "Safety Dance" - Men Without Hats "Time After Time" - Cyndi Lauper

606: Brave Heart "Set Me Free" - Monotonix "Faithfully Remain" - Ben Harper

605: Instant Karma "Fire Escape" - Fanfarlo "Sarah" - Ray LaMontagne

603: Epic Fail "You Always Hurt The One You Love" (House sings)

601-602: Broken "No Surprises" - Radiohead "Little Cabin Song" - Billy Moon, Sharkey & Zooks from the Spark "Kinderszenen Op. 15 (Lydia plays Schumann on the piano) "Love Vigilantes" - Iron & Wine "Symphony No. 5 in C Minor, Op. 67: Allegro Con Brio" (House plays Beethoven on the piano) "Poison Pushy" - Stanton Moore "No Smoke Without Fire" - James Hunter "Impromptu #3 in B flat" (Lydia plays Schubert on the piano) "For He Is An Englishman" (House sings) "Harmonia" - Cass McCombs "I Do Not Fear Jazz" - Big Strides "Life" - Sly & The Family Stone "No Moon At All" "Night Train" "I Love Paris" - Cole Porter "Every Time We Say Goodbye" - Cole Porter "Kinderszenen, Op. 15" (House plays Schumann on the piano.) "Macarena/Macarena River Remix" - Los Del Rio "You're Nobody Till Somebody Loves You" - Hal Richter & Jay-Bird sing "The Magic Flute" (The Mozart song the music box plays) "Cello Suite #1, Prelude in G Major" (Silent Girl plays Bach on the cello) "Seven Day Mile" - The Frames