Guitar Hero Smash Hits is the fourth expansion to the Guitar Hero series published by Activision for the Xbox 360, PlayStation 2, PlayStation 3 and Nintendo Wii. It is to feature 48 songs from the five previous franchise games: Guitar Hero, Guitar Hero II, Guitar Hero Encore: Rocks the 80s, Guitar Hero III: Legends of Rock, and "Guitar Hero: Aerosmith", expanding them to include support for full band-play.

The story sequence of Guitar Hero Smash Hits ties in to the game's Career Mode, similar to that of the other more recent Guitar Hero games. Players are challenged by the "God of Rock" to play at various Wonders of the World venues. After successful completion of each venue, players earn clothing that may be used to customize their avatars.

All of the other World Tour modes are also present in Smash Hits, including single player and band career modes, and the 8-player "Battle of the Band" mode.

Similar to Guitar Hero World Tour, Smash Hits features support for four instruments: lead guitar, bass guitar, drums, and vocal. Master recordings are used for each song, and the songs have been developed with gameplay features in mind, such as open bass strumming and full band accessibility. The game also includes "Expert+" mode introduced in Guitar Hero: Metallica and its use of double-bass drum pedals.

Finally, Smash Hits has a Music Studio creation mode that is compatible with the "GHTunes" custom song-sharing service within World Tour and Metallica.

• Aerosmith: "Back in the Saddle" (1977)

• Ozzy Osbourne: "Bark at the Moon" (1983)

• Heart: "Barracuda" (1977)

• Avenged Sevenfold: "Beast and the Harlot" (2005)

• Kansas: "Carry On Wayward Son" (76)

• Anthrax: "Caught in a Mosh" (87)

• Warrant: "Cherry Pie" (90)

• Pantera: "Cowboys from Hell" (1991)

• Living Colour: "Cult of Personality" (2007)

• Judas Priest: "Electric Eye" (1982)

• Lynyrd Skynyrd: "Free Bird" (1973)

• The Sword: "Freya" (2006)

• Blue Öyster Cult: "Godzilla" (1977)

• Nirvana: "Heart-Shaped Box" (1993)

• The Exies: "Hey You" (2004)

• Pat Benatar: "Hit Me with Your Best Shot" (1980)

• Joan Jett and the Blackhearts: "I Love Rock 'n Roll" (1982)

• Twisted Sister: "I Wanna Rock" (1984)

• Queen: "Killer Queen" (1974)

• Rage Against the Machine: "Killing in the Name" (1992)

• Lamb of God: "Laid to Rest" (2004)

• Priestess: "Lay Down" (2006)

• The Police: "Message in a Bottle" (1979)

• AFI: "Miss Murder" (2006)

• Foo Fighters: "Monkey Wrench" (1997)

• Boston: "More Than a Feeling" (1976)

• Danzig: "Mother" (1988)

• Queens of the Stone Age: "No One Knows" (2002)

• Poison: "Nothin' but a Good Time" (1988)

• Extreme: "Play With Me" (1989)

• Reverend Horton Heat: "Psychobilly Freakout" (1990)

• Slayer: "Raining Blood" (1986)

• Kiss: "Rock and Roll All Nite" (1975)

• Ratt: "Round and Round" (1984)

• Motley Crue: "Shout at the Devil" (1983)

• Deep Purple: "Smoke on the Water" (1972)

• Incubus: "Stellar" (1999)

• Jane's Addiction: "Stop!" (1990)

• The Donnas: "Take It Off" (2002)

• Franz Ferdinand: "Take Me Out" (2004)

• Alice In Chains: "Them Bones" (1992)

• DragonForce: "Through the Fire and Flames" (2006)

• White Zombie: "Thunder Kiss '65" (1992)

• Stone Temple Pilots: "Trippin' on a Hole in a Paper Heart" (1996)

• Iron Maiden: "The Trooper" (1983)

• Helmet: "Unsung" (1992)

• Wolfmother: "Woman" (2006)

• Rush: "YYZ" (1981)