Guitar Hero: Aerosmith is the fifth entry and second spin-off in the Guitar Hero series of rhythm video games, featuring the song catalog and career highlights of the rock band, Aerosmith. A stand-alone game, Guitar Hero: Aerosmith incorporates many of the features of Guitar Hero III: Legends of Rock.

Set lists start with play in the opening act as a rhythm character from the original Guitar Hero III: Legends of Rock band. After playing a song with those original characters, Aerosmith makes a dramatic entrance and the journey through Aerosmith's career begins. Gameplay follows the band through various positive achievements in its history, spanning from its first show at Nipmuc Regional High School in 1970 to the 2001 Super Bowl XXXV half-time show. Play will begin as Joe Perry. Brad Whitford and Tom Hamilton will be unlocked as play progresses. Other bands that are either inspired by Aerosmith or have toured with them are also included. A guitar-shaped peripheral is used to simulate the playing of rock music.

Guitar Hero: Aerosmith will be available as both a standalone disc and as part of a bundle. The bundle includes:

1. Guitar controller
2. Red faceplate with "Aerosmith" and "Walk This Way" in white letters
3. Tour book listing the songs featured in the game
4. Available for Xbox 360, PS3, Wii
5. PS2 bundle includes Kramer Wireless controller featured in Guitar Hero III: Legends of Rock