Greys Anatomy Spoilers

This pages contains rumors, secrets and spoilers for season five of Grey's Anatomy. The show's creator Shonda Rhimes is notoriously tight-lipped about releasing spoilers, but this page provides the best leads and links. Some of the potential spoilers for season five of Grey's Anatomy are included below.

Sadie (Melissa George) will joins the cast as a bisexual intern and Meredith's best friend.EW: Mer's Bisexual BFF Declares, "Something Did Happen" (October 27, 2008) She will leave by the end of the season.EW.com: Melissa George Checks Out (January 12, 2009)

Guest star Kevin McKidd may leave the show to star in the film adaption of the HBO series Rome.Eonline: Is GA Hotting Leaving Town? (December 1, 2008)

Tyne Daly will star as Derek Shepherd's mother.TV Squad: Tyne Daly as McDreamy's Mom (November 29, 2008) Dr. Callie Torres has been dating Dr. Erica Hahn but when Dr. Hahn suddenly leaves Seattle Grace (November 5, 2008 episode) will Callie go back to Dr. Mark Sloan?YouTube: Sneak Peek of Grey's Anatomy Season 5 Premiere

Now that Dr. Meredith Grey and Dr. Derek Shepherd have reconciled once again, is "happily-ever after" possible?YouTube: Sneak Peek of Grey's Anatomy Season 5 Premiere

Seattle Grace brings in celebrated cardiac surgeon, Dr. Virginia Dixon (Mary McDonnell) to help boost the hospital's national ranking. Dr. Dixon has Asperger's syndrome which is characterized by eccentric behavior and a general social awkwardnessEW: Mary McDonnell's Secret Revealed (October 30, 2008)

Dr. Alex Karev and Dr. Izzie Stevens communicate very differently, Izzie wears her heart on her sleeve and Alex is the epitome of stoic but love may speak louder than words this timeYouTube: Sneak Peek of Grey's Anatomy Season 5 Premiere

Meredith's little sister, Lexie Grey, continues the family tradition of complicated romantic relationships by falling for her roommate, not to mention, Meredith's former one-night-stand, Dr.George O'MalleyYouTube: Sneak Peek of Grey's Anatomy Season 5 Premiere

After seeing the 'Big Picture'", Dr. Miranda Bailey decided to focus on her family and limit her professional responsibilities to her role as Surgical Resident. She turned over the daily operations of the Denny Duquette Clinic to Dr. Stevens but did Dr. Bailey make the changes in time to save her marriage?YouTube: Sneak Peek of Grey's Anatomy Season 5 Premiere

• EOnline: Is GA Hottie Leaving Town? (December 1, 2008)

• Air date: December 4, 2008

• Air date: November 20, 2008

According to TV Guide, a surgery goes awry.

• Air date: November 13, 2008

Mary McDonnell joins the cast playing brilliant heart surgeon with Asperger Syndrome. She enters on the heels of Dr. Hahns (played by Brooke Smith). Sasha Alexander also joins the cast as Meredieth Grey's long lost friend and new doctor at Seattle Grace's Hospital.

• Air Date: November 6, 2008

Dr. Hahn realizes that Izzy was responsible for the Denny's stole heart. Denny's ghost begins to haunt the halls of Seattle Grace.