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• The season five premiere of Grey's Anatomy airs on ABC on September 25, 2008. At the end of season four, Derek and Meredith had decided to give their on-again-off-again relationship one more chance but first, Dr. Shepard must end things with Rose, a OR nurse he had been dating. Lexie continues to pursue George as Alex and Izzie grow closer. Cristina treats an attractive patient, guest star Kevin McKidd as Major Owen Hunt. Meanwhile, Baily tries to improve the trauma ranking of Seattle Grace by stealing patients from other hospitals.EOnline!:Grey's Anatomy: Season Five by Five (September 18, 2008)

• Fast Facts

  1. Season: Five
  2. Premiere airs: September 25, 2008 9pm/8pm (central)
  3. Episode length: 2 hours
  4. Episode title: Dream a Little Dream of Me
  5. Network: ABC
  6. Creator: Shonda Rhimes

• Cast

  • Ellen Pompeo as Dr. Meredith Grey
  • Patrick Dempsey as Dr. Derek Shepherd
  • Sandra Oh as Dr. Cristina Yang
  • Katherine Heigl as Dr. Isobel "Izzie" Stevens
  • T.R. Knight as Dr. George O'Malley
  • Chandra Wilson as Dr. Miranda Baily
  • Justin Chambers as Dr. Alex Karev
  • James Pickens Jr as Dr. Richard Webber
  • Eric Dane as Dr. Mark Sloan
  • Sara Ramirez as Dr. Callie Torres
  • Chyler Leigh as Dr. Lexie Grey
  • Brooke Smith as Dr. Erica Hahn

• Guest Stars

  • Lauren Stamile as Nurse Rose
  • Kevin McKidd as Owen
  • Kathy Baker as Anna
  • Bernadette Peters as Sarabet
  • Mariette Hartley as Betty
  • John Getzas Michael

• Related Pages on Mahalo

  Im Not a Princess Lyrics | Grey's Anatomy Quotes | Grey's Anatomy | Greys Anatomy Wallpaper | Grey's Anatomy Cast | Greys Anatomy Spoilers | Grey's Anatomy Merchandise | Grey's Anatomy Episode Guide | Greys Anatomy Music | Ellen Pompeo | Patrick Dempsey | Sandra Oh | Aasha Davis

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