One of the side missions in the Grand Theft Auto series was originally thought to be the Ambulance Mission. It was described as follows: "When a player commandeered an ambulance, they would have the option to play the side mission, which would involve picking up injured citizens and taking them to the local hospital. Rewards for delivering patients to the hospital successfully and within the time limit would have been health restoration and Sprint upgrades."

Ambulances would typically be found next to hospitals. A team of paramedics would also show up if multiple civilians were killed. A player would then be able to steal an ambulance when the two paramedics revived the downed civilians. A player would be able to transport up to three patients in an ambulance at one time.

Grand Theft Auto IV is the ninth title in the long-running Grand Theft Auto series.

The game is set in a redesigned Liberty City, based on four of the boroughs of New York City and parts of New Jersey, the total area of the map is smaller than San Andreas. While smaller, the newly designed Liberty City is far more detailed and the largest individual city in the Grand Theft Auto series.

The game tells the story of Niko Bellic, an Eastern European immigrant who immigrates to Liberty City to live "the American Dream" with the urging of his cousin Roman. there is more to the story than Roman has let on and now Niko finds himself working with Roman and trying not to get in over his head.