In 2008, Langella reprised his Tony award winning role as former President Richard Nixon for the Peter Morgan film, Frost/Nixon, directed by Oscar winner, Ron Howard. Frost/Nixon earned Langella Oscar and Golden Globe nominations for Best Actor.GoldenGlobes.org: Nominations and Winners An Academy Award win would make him the tenth person to receive both a Tony and an Oscar for playing the same role.Los Angeles Times: Can Frank Langella win an Oscar and a Tony in the same year too? (October 8, 2008)

• "I liked Richard Nixon and I liked playing him. I don't think he'll ever be gone from me, because something about the man is just very powerful. His pain, and the obviousness of his pain, stays with you. It's not a sentiment that's new to any of us -- you could see it on him at all times, his discomfort in public -- but I discovered he could be equally funny and charming. He just wasn't a relaxed man, and was forever churning away, trying to achieve greatness."—Frank LangellaHNN: Frank Langella's Skills with Outsiders Lead to Presidential Role (November 28, 2008)

• "I said to Ron (Howard) in the rehearsal period that it might be a good idea for me if I stay inside the character when I'm on the set so that people react differently to the president, differently than they would react to anybody else. When I came out of the trailer the Assistant Director who walked me to the set would say, "Good morning Mr. President". Ron had obviously spread the word through the company so for those 40 days or so it was really wonderful to be the king."—Frank LangellaPost Chronicle: Frank Langella: "Call Me Mr. President" (November 25, 2008)

• 2006-2008: Richard Nixon in Frost/Nixon, stage and film versions
• 2006: Perry White in Superman Returns
• 2005: William S. Paley in Good Night, and Good Luck
• 1993: Bob Alexander in Dave
• 1987: Skeletor in Masters of the Universe
• 1981/1987: Sherlock Holmes in Sherlock Holmes
• 1979: Count Dracula in Dracula