Dirty Sexy Money follows the Darlings, an extremely wealthy New York City family. Nick George (Peter Krause), is hired by the family patriarch, Tripp Darling (Donald Sutherland), to clean up the family's messes and maintain some semblance of morality but can Nick maintain his moral center or will he be seduced by the power and money of the Darlings?

• Donald Sutherland as Tripp Darling
• Peter Krause as Nick George
• Jill Clayburgh as Letitia Darling
• William Baldwin as Patrick Darling
• Natalie Zea as Karen Darling
• Glenn Fitzgerald as Brian Darling
• Samaire Armstrong as Juliet Darling
• Seth Gabel as Jeremy Darling
• Zoe McLellan as Lisa George
• Blair Underwood as Simon Elder
• Lucy Liu as Nola Lyons