In March 2009, he and Julianne Moore joined the cast of The Special Relationship as Bill and Hillary Rodham Clinton.

On December 15, 2008, TMZ.com reported that Quaid had reached a settlement in the case and was awarded $750,000.TMZ: Dennis Quaid Settles with Cedars (December 15, 2008) The court papers stated, "The settlement is the result of extensive negotiations between the parties and their respective legal representatives, and is intended to avoid the time, expense and uncertainty of litigation."People: Quaid Settles Babies' Overdose for $750,000 (December 15, 2008)

In March 2009, Quaid returned to Cedars-Sinai Medical Center in Los Angeles with a camera crew from The Oprah Winfrey Show to investigate whether measures had been taken to prevent medical mistakes like the one he encountered in 2007 when his newborn twins were given an overdose of the medication Heparin.People: Dennis Quaid Returns to Hospital... (March 5, 2009)

• 1977: I Never Promised You a Rose Garden
• 1978: Our Winning Season
• 1980: The Long Riders
• 1981: The Night the Lights Went Out in Georgia
• 1982: Johnny Belinda
• 1983: Jaws 3-D
• 1987: The Big Easy
• 1987: Innerspace
• 1988: D.O.A.
• 1989: Great Balls of Fire
• 1993: Undercover Blues
• 1996: Dragonheart
• 1998: The Parent Trap
• 2000: Frequency
• 2002: The Rookie
• 2004: The Alamo
• 2004: The Day After Tomorrow
• 2004: Flight of the Phoenix
• 2005: Yours Mine And Ours
• 2006: American Dreamz
• 2008: Vantage Point
• 2008: The Express
• 2009: The Horsemen
• 2009: G.I. Joe