Miller got his big break as a cast member on Saturday Night Live, in 1985. From there he had numerous stints as host of various talk shows on HBO. He has also appeared in such movies as Madhouse, Disclosure, The Net, Bordello of Blood, Never Talk to Strangers, Murder at 1600, Joe Dirt, Let Go and most recently Amnesia.

1. "A good rule of thumb is if you've made it to thirty-five and your job still requires you to wear a name tag, you've made a serious vocational error." — Dennis Miller joke
2. "The easiest job in the world has to be coroner. Surgery on dead people. What's the worst thing that could happen? If everything went wrong, maybe you'd get a pulse." — Dennis Miller quote from the Underground Humor
3. "I went to a bookstore and asked the saleswoman where the Self Help section was. She said if she told me it would defeat the purpose." — Dennis Miller joke
4. "The biggest conspiracy has always been the fact that there is no conspiracy. Nobody's out to get you. Nobody gives a shit whether you live or die. There, you feel better now?" — Dennis Miller on conspiracies