There are no cheats for College Hoops 2K8, however there are 30 Xbox 360 achievements. Some achievements require players to create a custom playbooks and custom chants. There are also two Pontiac achievements. One achievement only requires players to be online and qualify for the tournaments. The second achievement requires players to be offline and win the tournament.

1. '07 Ohio State vs Florida: Win this matchup as either '07 Ohio State or '07 Florida. MOP difficulty.
2. '79 Indiana St vs Michigan S: Win this matchup as either '79 Indiana State or '79 Michigan St. MOP difficulty.
3. '88 Kansas vs Oklahoma : Win this matchup as either '88 Kansas or '88 Oklahoma. MOP difficulty.
4. 30 Online ranked wins: Accumulate 30 online ranked match wins.
5. ABL win: Play and win an ABL game in open or career legacy.
6. At the line: Shoot over 85% from the FT line with any team. Minimum of 15 FT attempts.
7. Beat Oden: Beat Greg Oden at all of his drills in All-American Training Challenge - CPU Duel mode.
8. Buzzer beater : Win a game with a buzzer beater shot.
9. Comeback: Start the 2nd half down by at least 15 points and win the game with any team.
10. Conference champion: Win a conference tournament championship in career legacy.
11. Custom chants: Create and save a custom chant using chant creator.
12. Defense: Hold the opponent to 35% shooting or below with any team.
13. Double double: Get a double-double with any player.
14. Drills domination: Beat all of the opponents in All-American Training Challenge - CPU Duel mode.
15. Drills medal: Earn gold in any of the drills in the All-American Training Challenge - Singles mode.
16. Fan support: Finish a season in career legacy with at least 90% average attendance.
17. Glass domination: Out rebound the opponent by at least 15 with any team.
18. Isomotion training: Successfully perform any of the Isomotion moves in Tutorial mode.
19. Job offer: Receive a coaching job offer from a school in a Power Conference in career legacy.
20. National champion: Win a national championship in legacy mode (open or career).
21. On fire: Make 5 consecutive 3PT shots in a game with any team.
22. Online ranked win: Play and finish an online ranked match and win
23. Over .500 : Finish a season in career legacy with a winning record.
24. Play designer: Create and save a custom playbook using play designer.
25. Pontiac (online): Qualify for the Pontiac Virtual NCAA® Final 4® and complete at least one game in the tournament.
26. Pontiac tournament (Offline): Complete and win a Pontiac NCAA® Tournament. Must play all games as the same school w/o simulating.
27. Swat team: Block at least 10 shots with any team.
28. Top recruit: Sign a recruit ranked Top 10 in the nation in career legacy.
29. Triple double: Get a triple-double with any player.
30. Upload And share: Upload a 2K Share file to the 2K Sports server.