The film picks up in the late 19th century in London, with Jonathan Harker (Keanu Reeves) and Mina Murray (Winona Ryder), who are in love. Harker, a young real estate agent, is sent by his employer to Transylvania to help secure the sale of some English property to Count Dracula, the buyer. When Count Dracula notices a picture of Harker's fiance Mina, he sees a striking similarity to his past love Elisabeta. The count leaves Harker trapped in the castle, prisoner to his seducing “bride” vampires, and flees to England to pursue Mina.

Through the Count's pursuits of Mina, and murder of family friend Lucy Westernra (Sadie Frost), a band of men close to Mina form a team of resistance: Professor Abraham Van Helsing (Anthony Hopkins), Dr. Jack Seward (Richard E. Grant), Quincy Morris (Bill Campbell) and Lord Arthur Holmwood (Cary Elwes) together learn of Dracula's intentions, and pursue him through London and eventually back to his castle in Transylvania.

1. Best Costume Design – Academy Awards
2. Best Effects, Sound Effect Editing – Academy Awards
3. Best Makeup – Academy Awards