Big Brain Academy: Wii Degree is a sequel to Big Brain Academy that was developed and published by Nintendo for the Nintendo Wii. Like its predecessor, it attempts to measure brain mass with games and puzzles within Test mode, Practice mode and various group modes.

1. Test mode: Twelve questions are presented in random order within each of the five categories for a total of sixty questions. Scores are determined by speed and accuracy. Difficulty levels are adjusted based on a player's score. The five categories are:
   • Identify
   • Analyze (Reason)
   • Compute (Math)
   • Visualize
   • Memorize (Memory)
2. Practice mode: Each of the fifteen minigames can be played separately to develop better scores and train your brain, increasing brain mass.
3. Group modes: There are three multiplayer modes that accommodate up to eight players.
   • Mind Sprint: Head to head split screen race to answer questions correctly.
   • Mental Marathon: Score the highest number of points within the time limit. An incorrect answer ends the game.
   • Brain Quiz: Answer as many questions from selected categories as possible within the time allotment.