What is the pathology behind Rhinosporodiosis ?
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M$3 Answers
1) Truma to the nasal Mucosa
2) The infective spores enters through the traumatized nasal mucosa
3) The spore multiply in the submucosa
4) Formation of Sporangia full of spore.
5)The spore burst through the germinal pore of the sporangia
6) the spores are Discharged int tissue.
7)Reactive Hyperplasia of the tissue
8) formation of Polypoid vascular mass. or Rhinosporodiosis.
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M$
The Merck Manual has nothing on this, but I did find this on a dermatology website:
"Clinical manifestations
The lesions affect mainly the nasal mucosa. Other areas involved are the lacrimal sac, ears, vulva and penis. Pinkish, papillomatous, fissured lesions develop which become fissured and bleed later one. Rectal and vaginal lesions present with the same manifestations."
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M$
IMG
Rhinoscleroma is a chronic granulomatous disease of the upper respiratory tract caused by a gram-negative organism, Klebsiella rhinoscleromatis. It is uncommon in the US, but is endemic in parts of Central and South America, Egypt, Africa, and Eastern Europe. Mucopurulent discharge characterizes the rhinitic stage, followed by mucosal thickening during florid stage (seen here). The disease resolves with marked fibrosis.
This is a sinonasal rhinoscleroma during florid stage with marked cellular infiltrates consisting of lymphocytes and plasma cells. There are many macrophages with clear to foamy cytoplasm (Mikulicz cells) that harbor Klebsiella rhinoscleromatis (see Warthin-Starry stain).
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