What is osteogenesis imperfecta?
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There are 4 types of OI, type 2 being the most severe..
As for famous people with this condition below is a list..
British Actor Nabil Shaban.
Jazz Pianist Michel Petrucciani.
American Actor Michael J. Anderson.
British Actress Julie Fernandez.
German Actor, Writer, and Ethicist Peter Radtke .
Music Producer Simon Eric Gilbert.
Playwriter Firdaus Kanga-Parsi .
American Olympic Bronze Medalist Doug Herland.
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M$
is a genetic bone disorder. People with OI are born with defective connective tissue, or without the ability to make it, usually because of a deficiency of Type-I collagen.This deficiency arises from an amino acid substitution of glycine to bulkier amino acids in the collagen triple helix structure. The larger amino acid side-chains create steric hindrance that creates a "bulge" in the collagen complex. As a result, the body may respond by hydrolyzing the improper collagen structure. If the body does not destroy the improper collagen, the relationship between the collagen fibrils and hydroxyapatite crystals to form bone is altered, causing brittleness.
As a genetic disorder, OI is an autosomal dominant defect. Most people with OI receive it from a parent but it can also be an individual (de novo or "sporadic") mutation.
Michael J. Anderson - Starpulse.com is a celebrity who suffers from osteogenesis imperfecta.
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According to Wikipedia, "People with OI are born with defective connective tissue, or without the ability to make it."
Wikipedia lists nine "Noted People" with this disorder, they are:
QUOTE
# American actor Michael J. Anderson (He also has Achondroplastic Dwarfism)
# British actress Julie Fernandez
# American Olympic bronze medalist coxswain Doug Herland
# Japanese Countertenor singer Yoshikazu Mera
# Jazz pianist Michel Petrucciani
# British actor Nabil Shaban
# Music Producer Simon Illa aka Eric Gilbert
# German actor, writer, and ethicist Peter Radtke
# Firdaus Kanga-LGBT Parsi playwright.
/QUOTE
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