2 years, 9 months ago
What gene mutation causes Sickle Cell Anemia?
Explain how the gene mutated.
Separate topics with commas, or by pressing return. Use the delete or backspace key to edit or remove existing topics.
You can leave an optional "tip" with Mahalo's virtual currency, Mahalo Dollars. If you are asking a difficult question that might require some research, or if you'd like a wide variety of feedback, a higher tip often leads to more answers to your question.
M$1 Answer
It's a autosomal recessive mutation in the HBB gene. This gene codes for hemoglobin.
No one knows precisely how it originally mutated. But it is now passed from parent to child. Because it is recessive, it is possible to carry the defective gene without suffering symptoms. Thus if two parents each are carriers, their child will have a 25% chance of having the disease, a 50% chance of being a carrier, and a 25% chance of having two normal copies of the gene.
No one knows precisely how it originally mutated. But it is now passed from parent to child. Because it is recessive, it is possible to carry the defective gene without suffering symptoms. Thus if two parents each are carriers, their child will have a 25% chance of having the disease, a 50% chance of being a carrier, and a 25% chance of having two normal copies of the gene.
You can leave an optional "tip" with Mahalo's virtual currency, Mahalo Dollars. If you are asking a difficult question that might require some research, or if you'd like a wide variety of feedback, a higher tip often leads to more answers to your question.
M$
Is there any gene therapy research being done to repair the HBB gene?