What are the known drug interactions for methylphenidate?
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For people taking blood pressure medications, Ritalin can inhibit the effectiveness of drugs used for treating hypertension. People taking MAO inhibitors should consult their doctor before taking the methylphenidate. It also can interfere with anticoagulants like coumadin, anticonvulsants like phenobarbital, and with tricyclics like desipramine. Anti-depressants, like Prozac, can also be adversely affected. Tell your doctor if you use a sodium bicarbonate, like Alka-Seltzer, or if you take potassium citrate or citrate acid. Washing the drug down with orange or grapefruit juice may decrease its potency as well.
Ritalin should not be used by any person with heart problems or abnormalities, a history of either high or low blood pressure, is bipolar, or has Tourette's syndrome. People with known drug or alcohol dependency should not take Ritalin because of its addictive qualities. As with any other drug, before starting on a treatment program, remind your doctor of the medications and any dietary supplements that you are taking. If you are taking an over the counter cold or allergy medicine with decongestants, make sure you mention that.
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There are major interactions with 16 drugs, 196 moderate drug interactions and 15 minor drug interactions.
The most common medications checked in combination with methylphenidate are as follows:
Abilify (aripiprazole)
Adderall (amphetamine/dextroamphetamine)
Advair Diskus (fluticasone/salmeterol)
Ambien (zolpidem)
Celexa (citalopram)
Cymbalta (duloxetine)
Effexor XR (venlafaxine)
Fish Oil (omega-3 polyunsaturated fatty acids)
Lamictal (lamotrigine)
Lexapro (escitalopram)
Lyrica (pregabalin)
Pristiq (desvenlafaxine)
Provigil (modafinil)
Seroquel (quetiapine)
Singulair (montelukast)
Vitamin B12 (cyanocobalamin)
Vitamin D (ergocalciferol)
Vitamin D3 (cholecalciferol)
Xanax (alprazolam)
Zoloft (sertraline)
Some drugs in combination with methylphenidate may increase the risk of seizures. In some cases, potentially fatal drug interactions can occur. Make sure to tell your doctor or pharmacist of any herbal products or non prescription products you are using before taking methylphenidate, particularly blood thinners.
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These are some known drug interactions of methyphenidate:
*if taken with adrenergic agonist drugs or permoline increases the risk from liver toxicity
*if taken with antidepressants can cause high blood pressure, hypothermia and convulsions
*if ingested with ethanol, a metabolite called ethyphenidate is formed through hepatic transesterification and increased the blood plasma levels of d-methylphenidate by up to 40%.
*inhibit the metabolism of anticoagulants and anticonvulsanst like phenobarbital, phenytoin, primidone
*it can cause serious adverse effect if use with clonidine
If taken in overdose, these are the signs and symptoms that primarily results from overstimulation of the Central Nervous System:
-vomiting
-agitation
-tremors
-muscle twitching
-convulsions
-euphoria
-confusion
-hallucination
-delirium
-sweating
-
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