My strategy is to level up whatever character in an RPG so that I'm over-leveled for the boss to come. For Pokemon, I do the same as @engles and I'm sure a lot of other people do the same, its quite a popular tactic.

For games like Legend of Zelda and Prince of Persia I would just jump around as much as possible and/or avoiding being hit as much as I could while I slowly picked the boss off little by little.

I was just playing Killzone 2 yesterday and I found myself vs this mini boss, my strategy was to hide behind a corner while my AI buddies would take all the damage, while I shot the boss in the head and back (He had propane tanks on his back) with my sniper rifle until he blew up.

In Street Fighter 4 I don't really consider Seth a boss, while playing as Ryu, you can pretty much just jump>forward punch, crouch punch Shoryuken him over and over again for each difficulty up to Hard, and then you can change it up with throws and Tatsumaki Senpukyaku (or however that's spelled)

So my strategy against bosses always comes down to this plan.
HP>1 = Win If you stick to the plan, you will eventually win.

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