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ilaksh
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BEST ANSWER  chosen by asker   |  ilaksh  |  December 30, 2008 03:14 AM
It looks like another bogus anti-aging scam. Also, I almost used the term "snake oil" but Wikipedia says that is a misnomer as snake oil does in fact have anti-inflammatory effects. And I think I may have found one of the casting calls for the people they convinced to come on the commercial and say those things (see sources).

Not only that, but I don't find those testimonials to be the least bit convincing. A few times I was sure I could detect that those individuals did not believe what they were saying. Or maybe some of them did, but there was nothing they reported that could not be attributed to the placebo effect.

Also, they did not look younger. They were just wearing makeup, as everyone does when they appear on television or in a movie.

If somehow there really was something active in this product, I would speculate that it might be related to human growth hormone which is a chemical that some anti-aging doctors will inject in patients to make them feel younger. There is quite a bit of controversy about whether hgh is safe or effective though. And most of those doctors will tell you that hormone levels are only a symptom of the aging process rather than an underlying cause. Anyway, its unlikely there is even something like hgh in the product and you certainly wouldn't want to take it if they were deceptive enough to pretend it was something else.

I believe that vitamins, supplements, and some specific substances can have substantive but generally not especially dramatic effects and for most vitamins I think its more a matter of making sure you aren't missing a minimum level of nutrients.

Although, there are some substances like resveratrol (or a related more powerful chemical they are working on) or hgh that might improve people's health or age-related disease significantly. The Wikipedia articles makes it sound uncertain as to whether this is really the case though.

The most convincing discussion of the causes and possible solutions to aging have come from a person named Aubrey de Gray.

Here's his TED talk on aging (see sources)

Of course, there are plenty of scientists that disagree with de Grey but I haven't heard any thinking that is as comprehensive as his.

If you want supplements that at least have some connection to science then Ray Kurzweil is selling quite of few of them. And although Kurzweil is quite possibly a bit off his rocker (he believes we will solve aging and he will probably be able to live forever) he is extremely intelligent (and usually quite logical) and I don't see anything about his supplements that are dangerous or likely to be misleading.

Kurzweil and his friend, although a bit carried away, don't claim that any of their substances are revolutionary youth rejuvenators because they are honest and they know better. They just think a lot of those things might help combat aging or its effects. If there really are the type of breakthroughs claimed by commercials like that then I believe that de Grey and Kurzweil and the like will make an announcement. But from what de Grey is saying its not likely to be one substance that comes out by itself because there are numerous complex problems to solve before we stop seeing significant aging effects. But I certainly would like to believe that de Grey is right when he says its possible to "cure" aging at some point.

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vitality-g...
vitality-guru  |  January 04, 2009 09:31 AM
Seems like you are trying to take the glory away from something that looks like it has potential to promote what you have a vested interest in. If you examine AGEOFF a little closer you will learn that this product is based on peer reviewed published research conducted in the US, Sweden and Japan. The combination of ingredients is also patent pending and research is continuing to be conducted on the 5 core compounds included at precise levels proven by human clinicals to support its core claims.

Here were some recent press release sent out over the wire on the company:

http://www.marketwire.com/press-release/Nuvocare-Health-Sciences-Inc-918608.html

It also appears the product is a regularly feature on the Shopping Channel in Canada. I know it is not easy to get on there if the science doesn't check out.
ilaksh
ilaksh  |  January 04, 2009 05:26 PM
1. Exactly what peer reviewed published research are you referring to?

2. What are the core claims? As far as I can tell they make vague dramatic statements about youth rejuvenation and then just let the actors make specific (unconvincing) statements.

Actually I found the Canadian shopping channel page and here are some claims:

Level 1: Genetic DNA Level - NuvoCELL is clinically proven to help protect the cellular level of your skin. NuvoCELL helps improve this by 12% and helps promote natural healthy new cell division.

-- I am 100% sure that this 12% is a made up number. Please provide some reference to the evidence that includes this 12% cellular level protection improvement and the natural promotion of "natural healthy new" cell division.

Level 2: Muscle Tissue Level - NuvoFIT works to effectively help with loose skin syndrome resulting from excess body fat and poor muscle tone.
-- These are two implied claims. One that taking it will improve muscle tone and other that it will reduce body fat. Specifically stated it will improve this syndrome although it does not say how. Please provide evidence of any such effect.

Level 3: Skin Surface Level - NuvoDERM is a new oral-compound clinically proven to help improve skin surface health from the inside-out.

-- This is really just a restatement of the "level 1" claims in a way that sells the external aspect.

These are quite obviously written by a marketer rather than a doctor. I can even see a few qualifying words like "natural healthy new" that hint that the author was at least slightly aware of the possibility of a lawsuit down the road.

3. Please provide a reference to the patent application.

4. If these are truly potent compounds with medical application supported by clinical trials then they need to be regulated by the FDA.

5. What makes you think that the Canadian Shopping channel verified the "science" involved in this product (or any other product)?

6. Who are you and what is your connection to AGEOFF?
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