According to the patent logged to the US, there are several preferred ways to manufacture artificial sweetener.
http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4304794.PN.&OS=PN/4304794&RS=PN/4304794

One of them is
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A suitable reactor vessel is charged with 10 gms of triglycerol and 1000 mg of THMDHC. The charge is stirred and the resulting solution is heated to 95.degree. C. for 20 minutes and then cooled to 20.degree. C. The reaction product obtained is then dissolved in 10,000 milliliters of water. The aqueous solution is clear and colorless and has, based on the dry substance, twenty-five times the sweetening power of crystalline sugar and has no aftertaste.
-- end qoute --

The above method is good for sweetening of food provided the ration is between 0.0001% to 5% by weight of the food.

There are five types of artificial sweeteners approved by the Food and Drug Administration: aspartame, saccharin, acesulfame-K, neotame, and sucralose.
For more detailed information, please check the following link.
http://www.fda.gov/fdac/features/2006/406_sweeteners.html
The article

Please note, the article might be out of date as it is dated August 2006.
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