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Do any gene therapies exist which mutated DNA can be repaired?
Can scientist program a repair for damaged DNA?
Is cancer solvable?
Is cancer solvable?
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Yes, they exist.
There are two types of Gene therapy:
* Germ Line Gene Therapy
Where germ cells (sperm or eggs) are modified introducing functional genes integrated into their genomes. Thus, the change by the therapy will be passed onto later generations. This approach should be in theory effective in counteracting genetic disorders. The application of this treatment on human beings is presently prohibited in many places for various reasons, among them the ethical aspect of it.
* Somatic Gene Therapy
Where therapeutic genes are transferred into a patient´s somatic cells. Here, all modifications and effects will be restricted to the patient only, and will not be inherited by the patient's sons.
Among the vehicles or viral vectors in gene therapies are:
* Viruses
* Retroviruses
* Adenoviruses
* Adeno-associated viruses
* Pseudo typed viruses
Among the non-viral methods in gene therapies are:
* Naked DNA
* Oligonucleotides
* Lipoplexes and Polyplexes
Among the hybrid methods in gene therapies are:
* Virosomes
* Cationic lipids
* Hybridizing viruses
The first approved gene therapy procedure was made in September 1990 to Ashanthi DeSilva a 4 year old child born with Severe Combined Immunodeficiency (SCID). Despite the controversy and hard road this first procedure endured, it proved successful in the long term and with no noticeable side effects. Today with 23 years, she is still in good health, and attending college.
As of 2007 many gene therapies had appeared capable of handling a great variety of cancer illnesses. Some therapies deal with 25 nanometers liposomes able to carry therapeutic DNA through pores in the nuclear membrane; in others, scientists have successfully treated metastatic melanoma in patients using killer T cells genetically retargeted to attack the cancer cells.
Gene Therapy using an Adenovirus Vector to make a functional protein.
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Which gene therapies are past clinical testing and being applied in patient care?
voted helpful: davepamn
Stem-cell gene therapy
Belmonte team applied gene therapy to fix the mutated gene that causes FA.Those repaired cell were then programed into IPS cells that were indistinguishable from human embryotic cells and iPS cells come from healthy
donors.
A program of breeding between mHR6A+/-females and mHR6A--/Y was set up to repair damaged DNA
Cancer is currently not a solvable problem.
Belmonte team applied gene therapy to fix the mutated gene that causes FA.Those repaired cell were then programed into IPS cells that were indistinguishable from human embryotic cells and iPS cells come from healthy
donors.
A program of breeding between mHR6A+/-females and mHR6A--/Y was set up to repair damaged DNA
Cancer is currently not a solvable problem.
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