Yes! Abosolutely!

If you're using wired controllers, then all you have to do is plug into USB and play, if you want to use wireless, you'll need the wireless adapters for PC, and each one supports up to 4 xbox controllers:

http://www.xbox.com/en-US/hardware/x/xbox360wirelessgamingreceiver/

http://www.xbox.com/NR/rdonlyres/E8E4C1E6-9A98-4FD5-9219-53381586EBFC/0/boxpcWirelessAdapter.jpg

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Will work with future Xbox 360 Wireless Accessories.
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Provides up to a 30-foot range for complete wireless freedom.
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Use up to four Wireless Controllers and four Wireless Headsets simultaneously with one Wireless Gaming Receiver.
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Easily integrates with PC gaming scenarios and utilizes the same binding technology as Xbox 360.
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Provides a great value by eliminating the need for additional accessories for Windows-based gaming at an attractive price point.
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Plugs into a PC USB port and has a six foot cable. (NOTE: The Wireless Gaming Receiver requires a powered USB port to operate. If you're using the Wireless Gaming Receiver with a USB hub, the USB hub must have an external power source.)
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Future drivers available for Windows Vista™ and Force Feedback for the Wireless Racing Wheel.

Asker's Rating:

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