Those tags are more specifically called hashtags.

Twitter itself does nothing with the hashtags. (Other microblogging services like Identi.ca do.) However, you can use Twitter search to specifically find or exclude individual tweets marked with the hashtag.

You can ignore tweets containing a specific hashtag using this Greasemonkey script:
http://userscripts.org/scripts/show/41201

If you only want to follow a specific hashtag, I'd use Twitter search (http://www.summize.com) and search for #keyword, then subscribe to the RSS feed for that search.

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