Stay in San Diego ! Bring in your own food, don't drink the water or suck on the ice cubes !!!
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pepto bismal tablets prior to every meal starting 2 weeks prior to your visit
Source(s):
physician advise

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Couple of things you can do that would actually help in almost any situation...
1) Drink lots of water (in most cases bottled of course)
2) Get lots of rest
3) Don't eat too much street vendor food

To be honest, my travels throughout that area and South America suggest that getting sick is one of the side effects of REALLY exploring. That means eating street food, and going to random areas that may not always be the cleanest. My suggestion is that if you feel uncomfortable, then you're doing something different, and that's the best part of travel.
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I always travel to mexico, im half mexican so we go down their alot to our house in Baja, and Morelia. All the times ive ever gone it has never made me sick. Though the water is bad we usually bought purified water but i also went to the local outdoors store and bought the solution that purifies water. Thats about all the foods good, just wash any vegatables and fruit you get. Also make sure all your meat is thoroughly cooked to kill any bacteria that may be in it.
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This is one thing everyone forgets: Don't take ice on any of your drinks! Ice is made from the same tap water that will make you sick so avoid it at all costs. Don't eat salads either because they will have been washed with tap water or you don't know if the produce has been washed properly.
Another one is not to wipe the mouth of cans and bottles before you drink from them and of course wash your hands a lot.
And brush your teeth with bottled or water that you've boiled.

In terms of medical prevention:
Get vaccinated (if you haven't already) for Hepatitis A. Hepatitis A is common in developing countries as it is frequently in badly washed/unwashed fruits and vegetables and could be in the water. My grandfather caught Hep A in Mexico. NOT fun.
And make sure to go see a doctor and get your traveller's diarrhea medication prescription.
Source(s):
http://www.cdc.gov/hepatitis/hepatitisA.htm
http://www.ehso.com/ehshome/FoodSafety/FoodSafetyTravel.htm

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1) Drink only trusted brand bottled water.
2) Avoid ice in drinks (ask for the bottle).
3) Avoid alcohol (alcohol in Mexico doesn't always meet the standards of U.S. sold alcohol).
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Here is the key thing people miss. They don't drink the water...but they take a big slurp when they're in the shower...guess what? That's water!!
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Generally, anything you cook yourself will be fine. Fresh foods should be washed in a diluted bleach solution and then rinsed with clean water. Bottled water is always preferable, although filters can help sometimes.

Any beverages pre-sealed in bottles or cans should be fine. However, never, EVER, buy food from streetside food stands -- in almost all circumstances it has not been properly cleaned or refrigerated, and in many cases not properly cooked either. It is best to stick to well-to-do restaurant establishments (the few that exist -- most are in tourist areas or at least downtown), and sometimes it is best to check in the back to make sure that they are properly refrigerating ingredients and maintaining hygienic conditions.
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Death prevents illnous
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Don't drink the water!
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