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According to http://www.rxmed.com/b.main/b2.pharmaceutical/b2.1.monographs/CPS-%20Monographs/CPS-%20%28General%20Monographs-%20A%29/AMOXICILLIN.html the elimination half life of Amoxicillin for people with normal renal function ranges between 0.7 and 1.4 hours. This means that after that length of time, the amount of the antibiotic in the body has dropped by half. After twice that length of time, it drops by factor 4. After three times that period, by factor 8, etc. Thus, after 6 hours after peak concentration (assuming a patient in which the elimination half-life is 1 hour) there is only 1/(2^6) or 1/64 as much of the drug as there was at the peak.
A more complete description of the pharmacokinetics of this drug is described in the above-mentioned page:
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Amoxicillin is rapidly absorbed by the gastrointestinal tract after oral administration and is stable in the presence of gastric acid. Peak serum concentrations are usually attained within 1 to 2 hours following oral administration and are generally 2 to 2.5 times greater than those obtained with an equivalent dose of oral ampicillin. Amoxicillin diffuses readily into most body tissue and fluids, with the exception of the cerebrospinal fluid, although higher concentrations of the drug may be attained in patients with inflamed meninges. Amoxicillin is not highly protein bound. Its elimination half-life ranges from 0.7 to 1.4 hours in patients with normal renal function. Amoxicillin is partially metabolized to microbiologically inactive metabolites and both are then rapidly excreted in urine. Small amounts of the compounds are excreted in feces and bile.
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A more complete description of the pharmacokinetics of this drug is described in the above-mentioned page:
- quote -
Amoxicillin is rapidly absorbed by the gastrointestinal tract after oral administration and is stable in the presence of gastric acid. Peak serum concentrations are usually attained within 1 to 2 hours following oral administration and are generally 2 to 2.5 times greater than those obtained with an equivalent dose of oral ampicillin. Amoxicillin diffuses readily into most body tissue and fluids, with the exception of the cerebrospinal fluid, although higher concentrations of the drug may be attained in patients with inflamed meninges. Amoxicillin is not highly protein bound. Its elimination half-life ranges from 0.7 to 1.4 hours in patients with normal renal function. Amoxicillin is partially metabolized to microbiologically inactive metabolites and both are then rapidly excreted in urine. Small amounts of the compounds are excreted in feces and bile.
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