2 years, 10 months ago
how is tamiflu resistance tested (to identify flu resistant to tamiflu treatment)?
this has been in the news, but i haven't seen anything explaining how resistance is confirmed. connected with this, but entirely optional to an answer: (1) how long does it take to test one specimen for resistance? (2) when resistance was found in the news-reported cases, was it probably true that all of the flu virus in the person's body was resistant, or only a subset? (3) has loss of resistance--e.g., after a particular drug stops being widely used--ever been documented (probably in a lab, and not from people)?
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M$1 Answer
98 percent of this year's circulating H1N1 flu strains are immune to Tamiflu, compared with only 12 percent during the 2007-2008 flu season says an article in Scientific American in March 2009. Using a modified amplification refractory mutation system PCR (ARMS-PCR), you can simultaneously detect wild-type or mutant virus with the 274 mutation in a single PCR. It is a very specialised test and not widely available
Regards
Gamchek
Regards
Gamchek
You can leave an optional "tip" with Mahalo's virtual currency, Mahalo Dollars. If you are asking a difficult question that might require some research, or if you'd like a wide variety of feedback, a higher tip often leads to more answers to your question.
M$
Great Answer!
Nicely done, @gamchep, and welcome to Mahalo!
Nice Job !