Look carefully at the rash. If it's spreading, especially quickly, you might not want to mess with OTC meds at all.
If you know its source, and can specify certain attributes (is it oozing? is it mild and just a bit itchy?) then go check out some OTC meds and look for the description of what the medication will treat. It might just be topical and easily treated to relieve the itch with something like Tea Tree Oil (this is what I use for itch and mild rash relief) until the rash goes away.

However, if the rash is spreading, it may have been caused by something like a black widow bite, and that's nothing to mess with. Rash is one of the symptoms.

Symptoms of Black Widow and Brown Recluse Bites
Basically, be sensible. Especially if you have other symptoms (see the spider bite link), head for the ER. This is just one example of a rash that requires immediate attention and treatment as opposed to a small annoying itch that will go away swiftly.
Best info? Know the source of the rash!
Source(s):
http://www.emedicinehealth.com/wilderness_black_widow_and_recluse_spider_bi...


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