Unfortunately, there's not much science on this subject. The stuff that is out there is reallyt hard to find.

A lot depends on your goals. If you want certain muscles to be big, or if you want an overall increase in muscle mass.

I personally like the idea of full body workouts more, for a few reasons. One, you are using the smaller muscle groups, which you may ignore if you are targeting areas. Two, it keeps things dynamic and interesting so I get bored less.

Something else to keep in mind is what system you like best. If you are somebody who loves lifting weights or doing crunches, and you prefer doing the same routine every day, then targeted training may be easier for you to do.

But if you are the kind of person who needs variety and dynamics in your workout, doing a full-body workout might be easier for you to stick with.

Even if one method is better than the other, if you are not working out, you are not getting benefits.

I'd suggest expirmenting with both approaches and see which one works best for you, and which one gives you best results. No reason to stick with one thing forever, after all.
Source(s):
http://www.vhi.ie/hfiles/hf-331.jsp
http://www.bodybuilding.com/fun/wotw101.htm

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