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February 18, 2009 11:32 AM
can prader willi have a baby
wil it be success and both will be alive will baby be healthy or be disability
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| February 18, 2009 01:30 PM |
Source(s):
http://torontoist.com/2006/08/praderwilli_syn_1.php
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Other Answers (1)
February 18, 2009 04:14 PM
One of the major criteria of the syndrome is infertility as a result of hypogonadism. This does not mean people with PWS are infertile, however. In one study (Testicular histology in boys with Prader-Willi syndrome: fertile or infertile?) researchers found "CONCLUSIONS: Prader-Willi syndrome appears to be a heterogenic disorder with respect to testicular histology. Although most boys showed absent spermatogonia, 2 of 8 had normal testicular histology. Therefore, it is suggested that it is uncertain what the fertility outcome is in boys with Prader-Willi syndrome." Also, from an article in Gene Reviews: "With rare exception, individuals with PWS do not reproduce." but "Recent reports of fertility in two women with PWS raise the issue of the need for birth control [Akefeldt et al 1999, Schulze et al 2001]."
As to whether a resulting child would carry the genetic mutation for PWS, it depends on how the mutation occurred. There is a 50% risk of the child having Angelman Syndrome or PWS. The Gene Reviews article discusses offspring of someone with PWS.
Families should work with a genetic counselor to determine the type of syndrome and discuss future sexual activity.
Many more resources are available at http://www.nlm.nih.gov/medlineplus/praderwillisyndrome.html
Source(s):
http://www.ncbi.nlm.nih.gov/portal/utils/pageresolver.fcgi?log$=activity&recordid=1234972729276278
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=pws
http://www.nlm.nih.gov/medlineplus/praderwillisyndrome.html
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