George says she simply wants to "do something else." Already? Well, a Grey's insider does suggest that the parting of the ways was more mutual than simply the actress' choice. "Melissa's arc came to a natural end. Everyone at the show adores her. We're genuinely sad to see her go."
Source(s):
http://ausiellofiles.ew.com/2009/01/greys-anatomy-1.html

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She was never intended to be there forever. She was hired for a "multi-episode arc". The arc is done.
Source(s):
http://ausiellofiles.ew.com/2008/09/melissa-george.html
http://www.afterellen.com/blog/stuntdouble/melissa-george-leaves-greys-anat...

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To live a life outside of being in Grey Anatomy
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Though, the actress has said that "It was my ", it seems that it was more of a mutual decision than simply her choice according to a Grey's Anatomy insider . The reason that she gave was that she simply wants to "do something else."

http://www.greysanatomyinsider.com/images/gallery/intern-sadie_383x574.jpg

Melissa George isn’t leaving Grey’s Anatomy because she had a fight with a co-star, or because she’s a screaming homophobe, or because she’s a prissy diva who wanted more screentime, as was reported in some rumours some time ago.

George's initial deal called for her to appear in roughly 8-11 episodes with an option to become a series regular, like Kevin McKidd. But her Sadie had a much more rocky introduction than the Iraq doc, what with the self-mutilation and ambiguous sexuality. The latter characteristic was especially ill-timed coming off of Hahn's controversial exit. "The character was cursed from Day One," sniffs an ABC source. "She was very difficult to root for."

George concedes that Sadie was unconventional, even by Grey's standards. But recent episodes had revealed a calmer, gentler side to her. "When you take out your insides and you're hitting on every guy and girl in the hospital… you have to pull back," her portrayer suggests. "She's a doctor. You have to be professional. For her, she had to stop doing that or else she would've been kicked out."
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