I believe Amtrak does
Source(s):
http://www.cwrr.com/Amtrak/ne_em_w.html#P1

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Yes you can take a train. It takes about 9 hours.
You can drive, it's about 6 hours.
You can bicycle, it's about 30 hours.
You can walk. It's about 120 hours.
You can fly. It's about 1 1/2 hours.
Just listing for a sense of the distance. For cost, I'd estimate bicycling would be cheapest, unless you walk that long without sleeping or sleep in the bushes.
Safety, who knows? Everything is dangerous. Rail may be safest, but flying is close.
Source(s):
http://www.amtrak.com/servlet/ContentServer?pagename=Amtrak/Routes_Page&...@product%3D'Rail'">@product%3D'Rail'/travelSelection/journeySelection1/departLocation/search&wdf_cmsorigin=Buffalo+-+Exchange+St.,+NY+(BFX)&xwdf_cmsdestination=sessionWorkflow/productWorkflow@product%3D'Rail'">@product%3D'Rail'/travelSelection/journeySelection1/arriveLocation/search&wdf_cmsdestination=Newark+-+International+Airport,+NJ+(EWR)&_xpath%3DsessionWorkflow/productWorkflow@product%3D'Rail'">@product%3D'Rail'.x=15&_xpath%3DsessionWorkflow/productWorkflow@product%3D'Rail'">@product%3D'Rail'.y=10&xwdf_cmsdestinationSelect=sessionWorkflow/productWorkflow@product%3D'Rail'">@product%3D'Rail'/travelSelection/journeySelection1/arriveLocation/selected&wdf_cmsdestinationSelect=Amtrak.Station.EWR
http://maps.google.com/maps?hl=en&tab=wl

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