Cherman is right.. Your car isn't well-sealed at all. There are plenty of air-vents and gaps in the seals in the doors and boot (trunk.) Just look at any video of what happens to a car when it lands in water.. achieving air-tightness is even harder than water-tightness.  ..I say don't even bother with the car's seals.  Wrap something around your head and wet it.

If you *really* can't move anywhere (like, the traffic is completely jammed up) you might want to seriously consider running for the nearest building. If the gas is a nerve-agent you're probably screwed anyway ..but getting up to a high-level might save you. (IMHO the gas will settle low.) Whether you go for the highest floor, or lowest least air-flow basement (that will be the real tricky thing with any building ..their systems are probably still circulating the air), what I think is going to save you with a building is water. Take off your top, wet it, and wrap it around your nose and mouth. When you get where you want to be, wrap it around your whole head and settle into a nice still-air corner. Maybe barricade yourself with furniture/laundry ..if you're truly lucky you might have a water bottle to help with re-wetting the top.

If you're in your car, and have water, again, everyone should take their top off (women too) :), wrap it around their nose+mouth (or whole head if not driving), and wet what covers your face (and ears)? ..or be more liberal if there's lots of water. Close all vents (internal circulation), and *no* fan or air-con going. I think the seals are bad enough that having the fans on won't help you at all.

If you don't have much of a chance to go anywhere quick, I'd suggest not moving at all.. driving at any speed is just gonna force the air through the lame seals of the ventilation. If you have some warning, driving to a car-park building might help (being high) ..if it's underground I don't know if it will help at all. ..whatever type, the highest level is probably best ..find a corner without air vents ..stop the car, turn off everything, close all car vents, and start with those wet head-masks if you haven't already. ..just don't move around much. (If there's a hyperactive kid on board, put a nintendo in their hand, and they better sit stillor I say they should be out of the car.) ;)

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