The T-rex would probably die out pretty quickly unless you were going to bring back all the large prey they survived on. Just not enough meat on humans ;)
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T-Rex would become extinct like all the other dangerous predators that man has eliminated.
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Well, it would depend on the era you mean for humans.

If we're talking the Dark Ages for example, a bit of gunpowder and a few horses, well
Here be Dragons!!
I think the T-Rex would be a formidable enemy and hard to beat.

If you mean if they existed now 2009
We'd probably wipe them out within a few decades, big game hunting in the extreme.

maybe preserve a few on an island somewhere :) like the movie Jurassic Park!
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They'd be wiped out, the same way that humans wiiped out wooly mammoths, cave bears, briar wolves, wooly rinosceri, ground sloths...

They were indeed horrible, but they weren't that clever. Modern cat snanning technology has enabled us to analyze the brain structure of t-rex's, and they were very similar to crocodiles, which means they basically just meandered about, biting anything that moved.

Even with pre-industrial technology, we'd just do things like dig spear-pits covered with camaflogue and then stand on the other side of a pit when we see a t-rex and wave our arms and hollar at it.

The thing is... they didn't run in packs. Evidently they were solitary, and territorial. Virtually every t-rex skeleton has bite marks on the bones that could have only come from other t-rex's (determined by fitting teeth to the dimensions of the bite marks).

Plus, they're so big... it wouldn't be easy to accidently stumble on one like can happen with a bear.

Now... velociraptors... *that* could present a challenge and might take some modern weaponry to deal with.
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Humans wouldn't allow them to live in public for fear of danger, and then PETA and the World Wildlife Federation would come in and put them on the most extreme Endangered Species list. There would be financially-backed campaigns to save the T-Rex, and it would become a bullet point for Sean Hannity and Barak Obama.

They would probably not be smart enough to be kept efficiently in a zoo. Where would you keep T-Rex? Nowhere. Yet, if they ran in the wild a lot of things would die. I'd say send them out in the desert in Nevada somewhere, cordon off a small ecosystem and don't allow it to become Jurassic Park. We could always drop a cluster bomb on the whole thing.

PETA would love that.
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