I'm not 100% sure which Ice Age movie you're reffering to, I'd need a little more info. But, the most memorable "encounter" Scrat has is with Sid in this scene in the second move (from Wikipedia):
Scrat had his acorn with him at one point after his being stomped out of a nest, he had little time to regroup with it, as the great ice dam behind him came crashing down, sending he and his acorn helplessly drifting through massives walls of water in a nest. Finally, Scrat had reached one of the walls that he was floating near, and began to climb it, using his acorn as a pickaxe, but rather ended up diverting the waters that had flooded the valley when the acorn had weakened the ice and broken through it, sending Scrat, his acorn and all of the water away. Scrat saved the animals but nearly died in the process.

Eventually, Scrat made his way to a heaven for squirrels where he was among many acorns and was about to approach a giant, golden acorn, but he was brought back to life on Earth when Sid the ground sloth performed CPR on him. Scrat, after waking up, realized that Sid had taken him from his heavenly acorn and attacked him in a frenzy.
Source(s):
http://en.wikipedia.org/wiki/List_of_characters_in_the_Ice_Age_films#Scrat

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