Angioedema is an inflammatory reaction beneath the surface of the skin, in contrast to urticaria (hives) which is an inflammatory response on the skin's surface. The condition can be brought about by an allergic reaction to certain substances.Mayo Clinic: Hives and Angioedema Mayo Clinic: Causes

A rare form of angioedema, HAE (aka Quincke's disease) can cause sudden and rapid swelling of the airway, genitals, digestive tract or limbs. There is generally no itching associated with HAE. It is caused by an inherited deficiency in or a defective form of a C1 inhibitor blood protein, which plays a role in regulating how the immune system functions. Up to 22% of people diagnosed with this condition die due to breathing problems.MedlinePlus: Hereditary Angioedema eMedicine: Pathophysiology Mayo Clinic: Hives and Angioedema

AAE is similar to HAE, in that the cause is associated with low levels of C-1 or a malfunctioning version of the protein. Some forms of the disease have been associated with lymphomas and leukemias.eMedicine: Pathophysiology

Angioedema can be caused by an allergic reaction to drugs, food, insect bites, animals and substances like latex. Allergic Angioedema is usually accompanied by hives.Mayo Clinic: Causes eMedicine: Pathophysiology

Certain medications, including ACE inhibitors, can cause angioedema. Although only about 0.1-0.2% of people taking ACE Inhibitors develop the problem, it is a serious complication, with an 11% mortality rate.

The symptoms of angioedema will vary depending on the areas that are affected. The main symptoms can include swelling, itching and/or pain at the site of inflammation. Other considerations include difficulty breathing if the area is in the airways and cramping in the abdomen if the digestive system is involved.Mayo Clinic: Symptoms MedlinePlus: Symptoms

There are several treatments available for angioedema. Medications available over the counter include antihistamines such as diphenhydramine. Some medications that can be prescribed by a health professional include prednisone, Clarinex, Zyrtec and hydroxyzine.Mayo Clinic: Treatments and Drugs

The content in this page is not a substitute for professional medical advice. Please contact your doctor if you think you have angioedema.

• eHealth Forum: Angioedemia Remedies (October 8, 2008)

• HealthBoards: Percocet Helping Swelling? Another Question on Angiodema (March 6, 2008)

• Live Journal: Angioedema (February 1, 2008)

• Leg's Life: Angioedema, You Can Kiss My Grits (January 29, 2008)

• WebMD: Are My Swollen Lips an Allergy (January 23, 2008)

• YouTube Video: Angioedema Blog (Time:9:38 ) Judy: Nicely Done

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