The Red Sox are the defending 2007 World Series champions. In 2004, and 2007, the Red Sox swept the Angels on their way to championships in Major League Baseball.

In 2008, the Angels won eight of nine regular season games against the Red Sox.

The Angels last won the World Series in 2002.

In the 2008 ALDS, the Boston Red Sox defeated the Los Angeles Angels in four games. The Red Sox won the first two games in Anaheim, lost game 3 in extra innings, then won game four with a walk off single by Jed Lowrie. The Red Sox advance to face the Tampa Bay Rays in the 2008 NLCS.MLB.com: Red Sox vs. Angels

• Best of Five Series, All Times are EST
• Game 1: Bos at L.A - 10 / 1 / 08 (10 PM)
  • Final Score: Red Sox 4, Angels 1
• Game 2: Bos at L.A - 10 / 3 / 08 (9:30 PM)
  • Final Score: Red Sox 7, Angels 5
• Game 3: L.A. at Bos - 10 / 5 / 08
  • Final Score: Red Sox 4 - Angels 5
• Game 4: L.A. at Bos - 10 / 6 / 08
  • Final Score: Red Sox 3 - Angels 2

1. Chone Figgins - 3B
2. Garret Anderson - LF
3. Vladimir Guerrero - RF
4. Mark Teixeira - 1B
5. Torii Hunter - CF
6. Juan Rivera - DH
7. Howie Kendrick - 2B
8. Mike Napoli - C
9. Erick Aybar - SS

1. Jacoby Ellsbury - CF
2. Dustin Pedroia - 2B
3. David Ortiz - DH
4. Kevin Youkilis - 1B
5. J.D. Drew - RF
6. Jason Bay - LF
7. Mike Lowell - 3B
8. Jed Lowrie - SS
9. Jason Varitek - C