Against Me! is a popular punk band from Gainesville, Florida, that formed in 1997 and released its major label debut, New Wave, a decade later. The band's adoption of folk, folk-rock and Country influences—including Billy Bragg and Johnny Cash—had a profound effect on the underground punk landscape of the late-1990s, through to the late 2000s. Like-minded acts such as This Bike is a Pipe Bomb and Ghost Mice continue to play in a style similar to that of Against Me!'s earlier work, while the band itself has moved on to a harder sound, with elements of post-punk.

Against Me!'s emergence, along with that of fellow Gainesville, FL band Hot Water Music, helped to put the Florida college town on the map as a major center of punk rock, comparable to Washington, DC in the 1980s, or Seattle in the early 1990s. Since 2002, Against Me!'s former label No Idea Records has organized The Fest, the nation's largest annual punk rock festival.

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