Activase (Alteplase)

Activase is a thrombolytic drug used in two forms. Cathflo refers to when it is used to clear clots in catheters, such as in cardiac catheterization. T-PA refers to when it is used to break down naturally-made clots, such as in stroke.

1. Drug Class: Tissue plasminogen activatorWebMD: TPA for stroke
2. Also known as Alteplase, Cathflo, and T-PA
3. Mechanism of Action: Increased activation of the enzyme, plasmin, which breaks down the clotting factor, fibrin.
4. Uses: cardiac catheterization, blood clot, stroke, DVT, heart attackWebMD: TPA for stroke
5. Must be given within 3 hours by IV, or within 6 hours if injected directly into the clot
6. Only used in the hospital settingWebMD: TPA for stroke
7. Not prescribed by personal physician or meant to be taken at homeWebMD: TPA for stroke

Activase is used in a number of clot-related illnesses, not merely strokes but also pulmonary embolisms and myocardial infarctions. Effectiveness is dependent upon timeframe, in the case of stroke -- if the drug is not administered within three hours, it is unlikely to provide any benefit (or six hours, in the case of injection directly through arterial catheters to the site of the clot). Because the substance dissolves blood clots, it can result in severe hemorrage if it is administered without caution. An unusual but recent application of the drug shows that it can reduce the need for amputation in frostbite patients.Archives Of Surgery: Reduction of the Incidence of Amputation in Frostbite Injury with Thrombolytic Therapy Disclaimer: The content in this page is not a substitute for professional medical advice. Please contact your doctor before taking Activase (Alteplase).

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